Well obviously there are already systems to prevent total discharge so that would not happen (even a zero mile left drain still leaves the HV battery in a state it will accept charge)...
However, "accepting charge" doesn't necessarily mean "able to crank the ICE" - which is
essential!
No AA will be able to help you, should the HV-battery fail!
(you do remember, that the Honda e:HEV drive train uses the HV-battery to crank the ICE?)
Addendum:
I still think that keeping the HV-system permanently active only to keep the 12V-battery charged would be a rather "marginal" idea - if it where a good one, I'm positive Honda's engineers would have considered/implemented it!
Let's face it: In the "olden days" you would have faced the very same problems if you where simply mistreating the car. So, just use the car as it was meant to be used, namely:
driven!
Why on earth would you shell out 20 something K for a car only to be sitting in it listening to the radio?