According to the manual that should not be able to happen.
Lockout Prevention
If you forget and leave the key in the
ignition switch, Lockout Prevention
will not allow you to lock the driver’s
door. With the driver’s door open
and the key in the ignition, the
master door lock switch (on some
types) is disabled. However, if the
driver’s door is not open, the master
door lock switch is not disabled. If
you try to lock an open driver’s door
by pushing down the lock tab, the
tabs on all doors pop out. Pushing
down the lock tab on the front
passenger’s door only locks that door.
